The founding of UPHSD was inspired by the parents of Antonio Tamayo, Jose G. Tamayo and his wife, Josefina Laperal Tamayo, who earlier founded what is now known as the University Of Perpetual Help System JONELTA, which has five campuses. The first campus established is the Perpetual Help College and Hospital in Manila to meet the local and international demand for nurses. Two years later (1970), the Perpetual Help College and Hospital Campus was founded in Malasiqui, Pangasinan, in response to the government’s program to promote health and educational development in the rural areas. This was followed by the founding of the third Campus at Perpetual Help School of Laguna, at Biñan, in 1976, and its medical school, the Perpetual Help School of Laguna Foundation. Thereafter, the Perpetual Help Campus at General Marcos Alvarez in Cavite, and the Perpetual Help Campus in Cauayan, Isabela were established, bringing the number of campuses to five.